Publications

2007 to date

• Complete inhibition of a polyol nucleation by a micromolar biopolymer additive. Wen. X.; Wang, S.; Ramji, R. Bulter, L.O.; Bagdagulyan, Y.; Kishishita, A.; Golen, J.A.; Rheingold, A.L.; Kim, S.K.; Goddard III, W.A.; Pascal, T.A. Cell Rep. Phys. Sci. 2022, 3, 100723. PMID: 35265868.
• Toxicity profiles and protective effects of antifreeze proteins from insect in mammalian models. Tran-Guzman, A.; Moradian, R.; Walker, C.; Cui, H.; Corpuz, M.; Gonzalez, I., Nguyen, C., Meza, P., Wen, X., Culty, M. Toxicology Letters, 2022, 368, 9-23, https://doi.org/10.1016/j.toxlet.2022.07.009. PMID: 35901986.
• Submilligram Level of Beetle Antifreeze Proteins Minimize Cold-Induced Cell Swelling and Promote Cell Survival. Omori K.; Gonzalez I.; Nguyen C.; Raminani S.N.; Deleon V.M.; Meza P.; Zamalloa J.; Perez R.G.; Gonzalez, N.; Komatsu, H.; Al-Abdullah, I.H.; Wen, X. Biomolecules. 2022, 12. doi: 10.3390/biom12111584. PMID: 36358934.
• Protein/ice interaction: high-resolution synchrotron X-ray diffraction differentiates pharmaceutical proteins from lysozyme. Bhatnagar, B.; Zakharov, B.; Fisyuk, A.; Wen, X.; Karim, F.; Lee, K.; Seryotkin, Y.; Mogodi, M.; Fitch, A.; Boldyreva, E.; Kostyuchenko, A.; Shalaev, E. J. Phys. Chem. B 2019, 123, 5690-5699.
• A beetle antifreeze protein protects lactate dehydrogenase under freeze-thawing, Rodriguez, C; Sajjadi, S.; Abrol, R.; Wen, X. Int. J. Biol. Macromol. 2019, 136, 1153-1160.
• Antifreeze proteins govern the precipitation of trehalose in a freezing-avoiding insect at low temperature. Wen, X.; Wang, S.; Duman, J.G.; Arifin, J.F.; Juwita, V.; Goddard III, W.A.; Rios, A.; Liu, F.; Kim, S.K.; Abrol, R.; DeVries, A.L.; Henling, L.M. Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 6683-6688.
• Molecular Recognition of Methyl α‑D‑Mannopyranoside by Antifreeze (Glyco)Proteins. Wang, S.; Wen, X.; DeVries, A.L.; Bagdagulyan, Y.; Morita, A.; Golen, J.A.; Duman, J.G.; Rheingold, A.L. J. Am. Chem. Soc. 2014, 136, 8973-8981 (Featured in C&EN News "New Roles for Antifreeze Proteins").
• Antifreeze Protein-Induced Selective Crystallization of a New Thermodynamically and Kinetically Less Preferred Molecular Crystal. Wang, S.; Wen, X.; Golen, J.A.; Arifin, J.F.; Rheingold, A.L. Chem. Eur. J. 2013, 19, 16104-16112.
• Thermodynamic analysis of thermal hysteresis: Mechanistic insights into biological antifreezes. Wang, S.; Amornwittawat, N.; Wen, X. J. Chem. Thermodynamics 2012, 53, 125-130.
• Expanding the molecular recognition repertoire of antifreeze polypeptides: effects on nucleoside crystal growth. Wang, S.; Wen, X.; Nikolovski, P.; Juwita, V.; Arifin, J.F. Chem. Commun. 2012, 48, 11555-11557
• Interaction of reduced nicotinamide adenine dinucleotide with an antifreeze protein from Dendroides canadensis: mechanistic implication of antifreeze activity enhancement. Wen, X.; Wang, S.; Amornwittawat, N.; Houghton, E.A.; Sacco, M.A. J. Mol. Recognit., 2011, 24, 1025-1032.
• NMR and DFT Investigation of Heme Ruffling: Functional Implications for Cytochrome c. Liptak, M.D.; Wen, X.; Bren, K. L. J. Am. Chem. Soc., 2010, 132, 9753-9763.
• Arginine, a key residue for the enhancing ability of an antifreeze protein of the beetle Dendroides canadensis. Wang, S.; Amornwittawat, N.; Juwita, V.; Kao, Y.; Duman, J.; Pascal, T.; Goddard, W.; Wen, X. Biochemistry 2009, 48, 9696-9703.
• Hofmeister Effects of Common Monovalent Salts on the Beetle Antifreeze Protein Activity. Wang, S.; Amornwittawat, N.; Banatlao, J.; Chung, M.; Kao, Y.; Wen, X. J. Phys. Chem. B, 2009, 113, 13891-13894.
• Effects of Polyhydroxy Compounds on Beetle Antifreeze Protein Activity. Amornwittawat, N.; Wang, S.; Banatlao, J; Chung, M.; Duman, J.G.; Wen, X. Biochim. Biophys. Acta 2009, 1794, 341-346.
• Polycarboxylates Enhance Beetle Antifreeze Protein Activity. Amornwittawat, N.; Wang, S.; Duman, J.G.; Wen, X. Biochim Biophys Acta, 2008, 1784, 1942-1948.
• Effects of Heme Pocket Structure and Mobility on Cytochrome c. Wen, X.; Patel, K; Russell, B. S.; Bren, K. L. Biochemistry 2007, 46, 2537-2544.

2006 and earlier

• Heme Axial Methionine Fluxion in Pseudomonas aeruginosa Asn64Gln Cytochrome c551. Wen, X.; Bren, K. L.Inorg. Chem. 2005, 44, 8587-8593. 
• Suppression of Axial Methionine Fluxion in Hydrogenobacter thermophilus Gln64Asn Cytochrome c552. Wen, X.; Bren, K. L. Biochemistry 2005, 44, 5225-5233.
• The Influence of Aqueous vs. Glassy Solvents on Protein Dynamics: Vibrational Echo Experiments and Molecular Dynamics Simulations. Massari, A. M.; Finkelstein, I. J.; McClain, B. L.; Goj, A.; Wen, X.; Bren, K. L.; Loring, R. F.; Fayer, M. D. J. Am. Chem. Soc. 2005, 127, 14279-14289. 
• The Redox Properties of Wild-type and Heme-binding Loop Mutants of Bacterial Cytochromes c Measured by Direct Electrochemistry. Ye, T.; Kaur, R.; Wen, X.; Bren, K. L.; Elliotta, S. J. Inorg. Chem. 2005, 44, 8999-9006.
• Folding, Conformational Changes, and Dynamics of Cytochromes c Probed by NMR Spectroscopy. Bren, K. L.; Kellogg, J. A.; Kaur, R.; Wen, X. Inorg. Chem. 2004, 43, 7934-7944.
• Heme Axial Methionine Fluxionality in Hydrogenobacter thermophilus Cytochrome c552. Zhong, L; Wen, X.; Rabinowitz, T. M.; Russell, B. S.; Karan, E. F.; Bren, K. L. Proc. Natl. Acad. Sci.U.S.A. 2004, 101, 8637-8642.